Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides
نویسندگان
چکیده
منابع مشابه
Oxidation and Glycolytic Cleavage of Etheno and Propano DNA Base Adducts†
Non-invasive strategies for the analysis of endogenous DNA damage are of interest for the purpose of monitoring genomic exposure to biologically produced chemicals. We have focused our research on the biological processing of DNA adducts and how this may impact the observed products in biological matrixes. Preliminary research has revealed that pyrimidopurinone DNA adducts are subject to enzyma...
متن کاملCopper-dependent formation of miscoding etheno-DNA adducts in the liver of Long Evans cinnamon (LEC) rats developing hereditary hepatitis and hepatocellular carcinoma.
Formation of etheno-DNA adducts in the liver was investigated in Long Evans cinnamon (LEC) rats, a Long Evans strain with hereditary abnormal copper metabolism, which develop spontaneous hepatitis and later hepatocellular carcinoma. Using an ultrasensitive immunoaffinity/32P-postlabeling assay (J. Nair et al., Carcinogenesis, 16: 613-617, 1995), the etheno adducts 1,N6-ethenodeoxyadenosine (eps...
متن کاملAPPLICATION NOTE Quantification of Urinary Etheno-DNA Adducts by Column-Switching LC/APCI-MS/MS
Lipid peroxidation induced etheno-DNA adducts are promutagenic and have been suggested to play a causal role in the development of human cancers. Therefore, human biomonitoring of etheno-DNA adducts in urine has been suggested as a potential marker for oxidative stress-related DNA damage. For quantitative determination, a column-switching LC/APCIMS/MS method was developed for simultaneous analy...
متن کاملQuantification of urinary etheno-DNA adducts by column-switching LC/APCI-MS/MS.
Lipid peroxidation induced etheno-DNA adducts are promutagenic and have been suggested to play a causal role in the development of human cancers. Therefore, human biomonitoring of etheno-DNA adducts in urine has been suggested as a potential marker for oxidative stress-related DNA damage. For quantitative determination, a column-switching LC/APCI-MS/MS method was developed for simultaneous anal...
متن کاملUltrasensitive UPLC-MS-MS Method for the Quantitation of Etheno-DNA Adducts in Human Urine
Etheno-DNA adducts are generated from the metabolism of exogenous carcinogens and endogenous lipid peroxidation. We and others have previously reported that 1,N6-ethenodeoxyadenosine (εdA) and 3,N4-ethenodeoxycytidine (εdC) are present in human urine and can be utilized as biomarkers of oxidative stress. In this study, we report a new ultrasensitive UPLC-ESI-MS/MS method for the analysis of εdA...
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ژورنال
عنوان ژورنال: Genes and Environment
سال: 2021
ISSN: 1880-7062
DOI: 10.1186/s41021-021-00199-x